BioVerde Inc.

In October 2003, a pre-venture project: Basic Research for Development of long-term preserving agents for bio-tissues at Kyoto University had been granted by Japan Science and Technology Institute. Since then, the study had been carried on for two years and half, ending in March 2006, when BioVerde Inc. was founded to take over its works and to put forward its research and development into business.

Address:

Creation Core Kyoto Mikuruma Building, Kajii-cho 448-5,

Mikurumamichi-dori Seiwainguchi-agaru, Kamigyou-ku,

Kyoto 602-0841, JAPAN

Phone & Fax.:

+81-75-950-6511

E-mail:

bioverde@bz01.plala.or.jp

Research & Development:

Green tea polyphenol were found to have the following effects:

• Can inhibit proliferation of mammalian cells
• Can normally differentiate Hemopoietic stem cell after
  long-time inhibition of proliferation
• Can preserve Human mesenchymal stem cell at room temperature

Additionally, it was found in basic researches that by addition of green tea polyphenols to conventional cell culture mediums or preservation agents, tissues from a living body can be preserved for several months, with their cellular activities kept, under an unfrozen condition.

Further, it was found that immuno-rejection can be remedied by treating cells or tissues with green tea polyphenols.

With the above results, BioVerde Inc. is pursuing the development of new preserving solutions for clinical use that allow longer-term preservation of cells, tissues and organs under unfrozen condition, and that also have inhibition effect of immunoreaction on transplant tissues and organs.

BioVerde Inc. is planning to go forward to developing applications of epigallocatechin gallate (EGCg), to drugs such as cardioplegic and antifungal agents.