参考文献
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バイオマテリアル領域：
PGA
▶Biological Evaluation of a Prototype Material made of Polyglycolic Acid and Hydroxyapatite. Journal of Hard Tissue Biology 24[4] (2015) 375- 384
PCL
▶The predominant factor influencing cellular behavior on electrospun nanofibrous scaffolds: Wettability or surface morphology? Materials & Design 216 (2022) 110580
LCL
▶Increased neuritogenesis on ternary nanofiber matrices of PLCL and laminin decorated with black phosphorus. Journal of Industrial and Engineering Chemistry 92 (2020) 226–235
▶Graphene oxide-functionalized nanofibre composite matrices to enhance differentiation of hippocampal neuronal cells. Materials Advances Issue9, 2020
メディカルデバイス領域：LYDEX
LYDEX
▶Elucidating the degradation mechanism of a self-degradable dextran-based medical adhesive. Carbohydr Polym. 2022 Feb 15:278:118949.
▶Controlling the degradation of an oxidized dextran-based hydrogel independent of the mechanical properties. Carbohydr Polym. 2019 Jan 15;204:131-141. doi: 10.1016/j.carbpol.2018.09.081. Epub 2018 Oct 3.
▶Dextran oxidized by a malaprade reaction shows main chain scission through a maillard reaction triggered by schiff base formation between aldehydes and amines. Journal of Polymer Science Part A: Polymer Chemistry / Volume 54, Issue 14. First published: 16 March 2016
▶Self-degradation of tissue adhesive based on oxidized dextran and poly-l-lysine Carbohydrate Polymers Volume 113, 26 November 2014, Pages 32–38
▶Low cytotoxic tissue adhesive based on oxidized dextran and epsilon-poly-l-lysine. J Biomed Mater Res A. 2014 Aug;102(8):2511-20. doi: 10.1002/jbm.a.34923. Epub 2013 Aug 30.
止血材
▶The effective control of a bleeding injury using a medical adhesive containing batroxobin." Biomed Mater. 2014 Apr;9(2):025002. doi: 10.1088/1748-6041/9/2/025002. Epub 2014 Jan 31.
▶Hemostatic effect of new surgical glue in animal partial nephrectomy models. Urology. 2013 May;81(5):1095-100. doi: 10.1016/j.urology.2013.01.002. Epub 2013 Feb 20.
▶Evaluation of Wound Closure and Antihemorrhagic Efficiency of Medical Adhesive Composed of Aldehyded Dextran and Poly(L-lysine). Biomaterials Research 15(3) : 129-135 (2011)
シーラント材
▶Development of new biodegradable hydrogel glue for preventing alveolar air leakage. J Thorac Cardiovasc Surg. 2007 Nov;134(5):1241-8.
▶Creation of a uniform pleural defect model for the study of lung sealants. J Thorac Cardiovasc Surg. 2007 Jul;134(1):145-51.
癒着防止材
▶Evaluation of the optimal dose for maximizing the anti-adhesion performance of a self-degradable dextran-based material. Carbohydrate Polymer Technologies and Applications 4 (2022) 100255
▶Prevention of retrosternal adhesion by novel biocompatible glue derived from food additives. J Thorac Cardiovasc Surg. 2013 Nov;146(5):1232-8. doi: 10.1016/j.jtcvs.2013.02.001. Epub 2013 Apr 10.
▶Novel powdered anti-adhesion material: preventing postoperative intra-abdominal adhesions in a rat model. Int J Med Sci. 2013;10(4):467-74. doi: 10.7150/ijms.5607. Epub 2013 Mar 5.
▶Novel biodegradable powder for preventing postoperative pleural adhesion. J Surg Res. 2013 Jan;179(1):e13-9. doi: 10.1016/j.jss.2012.01.056. Epub 2012 Apr 1.
内視鏡用創傷被覆材
▶Efficacy of a novel endoscopically deliverable muco-adhesive hemostatic powder in an acute gastric bleeding porcine model. PLoS One. 2019 Jun 11;14(6):e0216829. doi: 10.1371/journal.pone.0216829. eCollection 2019.
薬物徐放性基剤（DDS）
▶Aldehyded Dextran and ε-Poly(L-lysine) Hydrogel as Nonviral Gene Carrier. Stem Cells Int. 2013;2013:634379. doi: 10.1155/2013/634379. Epub 2013 Aug 21.
▶Topical application of a biodegradable disc with amiodarone for atrial fibrillation. Ann Thorac Surg. 2011 Mar;91(3):734-9. doi: 10.1016/j.athoracsur.2010.10.022.
スキャホールド
▶Development of a new tissue-engineered sheet for reconstruction of the stomach. Artif Organs. 2009 Oct;33(10):818-26. doi: 10.1111/j.1525-1594.2009.00808.x. Epub 2009 Oct 16.
▶Biodegradable Adhesive (LYDEX) with Hydroxyapatite Granules. 2007, Key Engineering Materials, 361-363, 575
眼科領域
▶An ex vivo model for suture-less amniotic membrane transplantation with a chemically defined bioadhesive.. Curr Eye Res. 2012 May;37(5):372-80. doi: 10.3109/02713683.2012.663853. Epub 2012 Mar 29.
▶Novel sutureless keratoplasty with a chemically defined bioadhesive. Invest Ophthalmol Invest Ophthalmol Vis Sci. 2009 Jun;50(6):2679-85. doi: 10.1167/iovs.08-2944. Epub 2009 Jan 10.
▶Sutureless amniotic membrane transplantation for ocular surface reconstruction with a chemically defined bioadhesive. Biomaterials. 2008 Jul;29(19):2923-31. doi: 10.1016/j.biomaterials.2008.03.027. Epub 2008 Apr 15.
整形外科領域
▶Strong adhesiveness of a new biodegradable hydrogel glue, LYDEX, for use on articular cartilage. J Appl Biomater Funct Mater. 2013 Dec 16;11(3):e180-6. doi: 10.5301/JABFM.5000164.
抗菌性
▶Antimicrobial effect of medical adhesive composed of aldehyded dextran and ε-Poly(L-Lysine). J Microbiol Biotechnol. 2011 Nov;21(11):1199-202.
▶Sustained release of vancomycin from a new biodegradable glue to precent methicillin-resistant Ataphylococcus aureus graft ingection. Interact Cardiovasc Thorac Surg. 2010 Jul;11(1):52-5. doi: 10.1510/icvts.2010.232447. Epub 2010 Apr 1.
消化器外科領域
▶Novel external reinforcement device for gastrointestinal anastomosis in an experimental study. BMC Surg. 2023 May 11;23(1):121.
ライフサイエンス領域：不凍ポリアミノ酸
細胞保存
▶Gene expression analysis of human induced pluripotent stem cells cryopreserved by vitrification using StemCell Keep. Biochem Biophys Rep. 2021 Nov 15:28:101172.
▶Molecular Design of Polyampholytes for Vitrification-Induced Preservation of Three-Dimensional Cell Constructs without Using Liquid Nitrogen. Biomacromolecules. 2020 Aug 10;21(8):3017-3025.
▶Cryopreservation of bovine somatic cells using antifreeze polyamino-acid (carboxylated poly-l-lysine). Cryobiology. 2017 Feb 1. pii: S0011-2240(16)30436-9. doi: 10.1016/j.cryobiol.2017.01.010.
▶Long-term cryopreservation of human mesenchymal stem cells using carboxylated poly-l-lysine without the addition of proteins or dimethyl sulfoxide. J Biomater Sci Polym Ed. 2013 Aug;24(12):1484-97. doi: 10.1080/09205063.2013.771318. Epub 2013 Feb 22.
▶Effective vitrification of human induced pluripotent stem cells using carboxylated ε-poly-l-lysine. Cryobiology. 2011 Oct;63(2):76-83. doi: 10.1016/j.cryobiol.2011.05.003. Epub 2011 May 20.
▶ Polyampholytes as cryoprotective agents for mammalian cell cryopreservation. 2010;19(6):691-9. doi: 10.3727/096368910X508780. Epub 2010 Jun 3.
▶Polyampholytes as low toxic efficient cryoprotective agents with antifreeze protein properties. Biomaterials. 2009 Sep;30(27):4842-9. doi: 10.1016/j.biomaterials.2009.05.025. Epub 2009 Jun 9.
軟骨細胞シート保存
▶Development of an efficient vitrification method for chondrocyte sheets for clinical application. Regen Ther. 2020 May 14:14:215-221.
▶Development of a novel vitrification method for chondrocyte sheets. BMC Biotechnol. 2013 Jul 25;13(1):58. [Epub ahead of print]
筋芽細胞シート保存
▶Development of a vitrification method for preserving human myoblast cell sheets for myocardial regeneration therapy. BMC Biotechnol. 2018 Sep 10;18(1):56.
スキャフォールド
▶Cell encapsulation and cryostorage in PVA-gelatin cryogels: incorporation of carboxylated ε▶L-lysine as cryoprotectant. J Tissue Eng Regen Med. 2012 Apr;6(4):280-90. doi: 10.1002/term.431. Epub 2011 Jun 27.
受精卵保存（不妊治療）
▶Successful vitrification of pronuclear-stage pig embryos with a novel cryoprotective agent, carboxylated ε-poly-L-lysine. PLoS One. 2017 Apr 27;12(4):e0176711. doi: 10.1371/journal.pone.0176711. eCollection 2017.
▶ The Beneficial Effect of Carboxylated Poly-L-Lysine on Cryosurvival of Vitrified Early Ste. Cryo Letters. 2017 Jan/Feb;38(1):1-6.
▶Development of a Low Toxicity and Completely Serum-Free Vitrification System Combining a Cryo-Nano-Hole Vitrification Container with Antifreeze Polyamino-acid (Carboxylated Poly-L-Lysine) for assisted reproductive technology (ART). J. Reprod. Engineer. 2011; Vol. 14 No. 2: 13-36.
精子保存（不妊治療）
▶Carboxylated Poly-L-lysine Potentially Reduces Human Sperm DNA Fragmentation after Freeze-Thawing, and Its Function Is Enhanced by Low-Dose Resveratrol. Cells. 2023 Nov 7;12(22):2585.
▶Carboxylated Poly-l-Lysine as a Macromolecular Cryoprotective Agent Enables the Development of Defined and Xeno-Free Human Sperm Cryopreservation Reagents. Cells. 2021 Jun 8;10(6):1435.
マウス生殖細胞保存
▶Successful production of offspring derived from mouse zygotes vitrified with carboxylated ε-poly-L-lysine and polyvinyl alcohol without serum. J Reprod Dev. 2023 Feb 8;69(1):53-55.
ウシ生殖細胞保存
▶Cryoprotective effect of antifreeze polyamino-acid (Carboxylated Poly-l-Lysine) on bovine sperm: A technical note. Cryobiology. 2018 Jun:82:159-162.
▶Cryopreservation of bovine somatic cells using antifreeze polyamino-acid (carboxylated poly-L-lysine). Cryobiology. 2017 Jun:76:140-145.
ブタ生殖細胞保存
▶Improved fertility of frozen-thawed porcine spermatozoa with 3,3-dimethylglutaric anhydride poly-L-lysine as a novel cryoprotectant. Anim Sci J. 2023 Jan-Dec;94(1):e13821.
▶Cryopreservation of pig spermatozoa using carboxylated poly-L-lysine as cryoprotectant. J Reprod Dev. 2022 Oct 6;68(5):312-317.
▶Carboxylated ε-poly-L-lysine, a cryoprotective agent, is an effective partner of ethylene glycol for the vitrification of embryos at various preimplantation stages. Cryobiology. 2020 Dec:97:245-249.
凍結機序
▶Antifreeze effect of carboxylated ε-poly-L-lysine on the growth kinetics of ice crystals. J Phys Chem B. 2014 Aug 28;118(34):10240-9. doi: 10.1021/jp507697q. Epub 2014 Aug 18.
DDS
▶Protein cytoplasmic delivery using polyampholyte nanoparticles and freeze concentration. Biomaterials. 2014 Aug;35(24):6508-18. doi: 10.1016/j.biomaterials.2014.04.030. Epub 2014 May 10.
ライフサイエンス領域：緑茶由来ポリフェノール
皮膚繊維芽細胞
▶Preventive effects of epigallocatechin-3-O-gallate against replicative senescence associated with p53 acetylation in human dermal fibroblasts. Oxid Med Cell Longev. 2012;2012:850684. doi: 10.1155/2012/850684. Epub 2012 Nov 18.
▶Epigallocatechin-3-gallate regulates cell growth, cell cycle and phosphorylated nuclear factor-κB in human dermal fibroblasts. Acta Pharmacol Sin. 2011 May;32(5):637-46. doi: 10.1038/aps.2011.17. Epub 2011 Apr 25.
▶In vitro antifungal activity of epigallocatechin 3-O-gallate against clinical isolates of dermatophytes. Yonsei Med J. 2011 May;52(3):535-8. doi: 10.3349/ymj.2011.52.3.535.
皮膚組織
▶Long-term preservation of rat skin tissue by epigallocatechin-3-o-gallate. Cell Transplant. 2009;18(5):505-12.
▶Green tea polyphenols affect skin preservation in rats and improve the rate of skin grafts. Cell Transplant. 2008;17(1-2):203-9.
組織バンク（移植）
▶A non-frozen living tissue bank for allotransplantation using green tea polyphenols. Yonsei Med J. 2004 Dec 31;45(6):1025-34. Review.
移植片対宿主病
▶Attenuation of murine graft-versus-host disease by a tea polyphenol. Cell Transplant. 2012;21(5):909-18. doi: 10.3727/096368911X623934. Epub 2012 Feb 13.
腎臓
▶Epigallocatechin-3-gallate protects kidneys from ischemia reperfusion injury by HO-1 upregulation and inhibition of macrophage infiltration. Transpl Int. 2011 May;24(5):514-22. doi: 10.1111/j.1432-2277.2011.01224.x. Epub 2011 Feb 3.
▶Protection of rabbit kidney from ischemia/reperfusion injury by green tea polyphenol pretreatment. Arch Pharm Res. 2007 Nov;30(11):1447-54.
▶Polyphenol, an extract of green tea, increases culture recovery rates of isolated islets from nonhuman primate pancreata and marginal grade human pancreata. Cell Transplant. 2004;13(2):145-52.
末梢神経
▶Storage and allogeneic transplantation of peripheral nerve using a green tea polyphenol solution in a canine model. J Brachial Plex Peripher Nerve Inj. 2010 Nov 28;5:17. doi: 10.1186/1749-7221-5-17.
▶Optimal conditions for peripheral nerve storageeen tea polyphenol: an experimental study in animals. Biotechnol Lett. 2005 May;27(9):655-60.
▶Peripheral nerve allografts stored in green tea polyphenol solution. Transplantation. 2005 Mar 27;79(6):688-95.
▶Successful storage of peripheral nerve before transplantation using green tea polyphenol: an experimental study in rats. Exp Neurol. 2003 Dec;184(2):688-96.
血管平滑筋細胞
▶Selective inhibitory effect of epigallocatechin-3-gallate on migration of vascular smooth muscle cells. Molecules. 2010 Nov 19;15(11):8488-500. doi: 10.3390/molecules15118488.
大動脈平滑筋細胞
▶Inhibitory effects of epigallocatechin-3-O-gallate on serum-stimulated rat aortic smooth muscle cells via nuclear factor-kappaB down-modulation. Biochem Biophys Res Commun. 2006 Jun 23;345(1):148-55. Epub 2006 Apr 27.
ヒト伏在静脈
▶Long-term preservation of human saphenous vein by green tea polyphenol under physiological conditions. Tissue Eng. 2005 Jul-Aug;11(7-8):1054-64.
▶Effects of green tea polyphenol on preservation of human saphenous vein. J Biotechnol. 2004 May 27;110(2):109-17.
▶Preservation of human saphenous vein against reactive oxygen species-induced oxidative stress by green tea polyphenol pretreatment. Artif Organs. 2003 Dec;27(12):1137-42.
ヒト繊維肉腫
▶Apoptosis of human fibrosarcoma HT-1080 cells by epigallocatechin-3-O-gallate via induction of p53 and caspases as well as suppression of Bcl-2 and phosphorylated nuclear factor-κB. Apoptosis. 2011 Jan;16(1):75-85. doi: 10.1007/s10495-010-0548-y.
微小血管内皮細胞
▶Prevention of reactive oxygen species-induced oxidative stress in human microvascular endothelial cells by green tea polyphenol. Toxicol Lett. 2005 Feb 15;155(2):269-75.
心臓
▶Oral pretreatment with a green tea polyphenol for cardioprotection against ischemia-reperfusion injury in an isolated rat heart model. J Thorac Cardiovasc Surg. 2011 Feb;141(2):511-7. doi: 10.1016/j.jtcvs.2010.04.016. Epub 2010 May 23.
▶A novel method of 'preparative' myocardial protection using green tea polyphenol in oral uptake. Interact Cardiovasc Thorac Surg. 2004 Dec;3(4):612-5.
骨軟骨
▶Biological and biomechanical evaluations of osteochondral allografts preserved in cold storage solution containing epigallocatechin gallate. Cell Transplant. 2010;19(6):681-9. doi: 10.3727/096368910X508771. Epub 2010 Jun 3.
関節軟骨
▶Nonfrozen preservation of articular cartilage by epigallocatechin-3-gallate reversibly regulating cell cycle and NF-kappaB expression. Tissue Eng Part A. 2010 Feb;16(2):595-603. doi: 10.1089/ten.TEA.2009.0484.
造骨細胞
▶Protection of osteoblastic cells from freeze/thaw cycle-induced oxidative stress by green tea polyphenol. Biotechnol Lett. 2005 May;27(9):655-60.
骨芽細胞
▶Protective effects of green tea polyphenol against reactive oxygen species-induced oxidative stress in cultured rat calvarial osteoblast. Cell Biol Toxicol. 2003 Oct;19(5):325-37.
血小板
▶Preservation of platelets by adding epigallocatechin-3-o-gallate to platelet concentrates. Cell Transplant. 2009;18(5):521-8.
ヒト幹細胞
▶Effects of epigallocatechin gallate on osteogenic capability of human mesenchymal stem cells after suspension in phosphate-buffered saline. Tissue Eng Part A. 2010 Jan;16(1):91-100. doi: 10.1089/ten.TEA.2008.0636.
足根繊維芽細胞
▶Reversible regulation of cell cycle-related genes by epigallocatechin gallate for hibernation of neonatal human tarsal fibroblasts. Cell Transplant. 2009;18(4):459-69. doi: 10.3727/096368909788809776.
ステント
▶Development of epigallocatechin gallate-eluting polymeric stent and its physicochemical, biomechanical and biological evaluations. Biomed Mater. 2009 Aug;4(4):044104. doi: 10.1088/1748-6041/4/4/044104. Epub 2009 Jul 8.
▶The behavior of vascular smooth muscle cells and platelets onto epigallocatechin gallate-releasing poly(l-lactide-co-epsilon-caprolactone) as stent-coating materials. Biomaterials. 2008 Mar;29(7):884-93. Epub 2007 Nov 26.
抗菌
▶Highly antibiotic-resistant Acinetobacter baumannii clinical isolates are killed by the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG). Clin Microbiol Infect. 2009 Apr;15(4):341-6.
肝細胞
▶reservation of porcine hepatocytes in three-dimensional bioreactor at room temperature using epigallocatechin-3-gallate. Tissue Eng Part C Methods. 2009 Sep;15(3):345-53. doi: 10.1089/ten.tec.2008.0483.
創傷被覆
▶Enhanced wound healing by an epigallocatechin gallate-incorporated collagen sponge in diabetic mice. Wound Repair Regen. 2008 Sep-Oct;16(5):714-20. doi: 10.1111/j.1524-475X.2008.00422.x.
抗腫瘍
▶Enhanced antitumor activities of (-)-epigallocatechin-3-O-gallate fatty acid monoester derivatives in vitro and in vivo. Biochem Biophys Res Commun. 2008 Dec 26;377(4):1118-22. doi: 10.1016/j.bbrc.2008.10.128. Epub 2008 Nov 5.
体内動態
▶Time-dependent intracellular trafficking of FITC-conjugated epigallocatechin-3-O-gallate in L-929 cells. Bioorg Med Chem. 2008 Nov 15;16(22):9652-9. doi: 10.1016/j.bmc.2008.10.009. Epub 2008 Oct 7.
哺乳類組織
▶Non-frozen preservation of mammalian tissue using green tea polyphenolic compounds. Biomed Mater. 2006 Mar;1(1):R18-29. doi: 10.1088/1748-6041/1/1/R03. Epub 2006 Mar 21. Review.
リンパ球培養
▶Tea polyphenol inhibits allostimulation in mixed lymphocyte culture. Cell Transplant. 2007;16(1):75-83.
ラット大動脈組織移植
▶Preservation of rat aortic tissue transplant with green tea polyphenols. Cell Transplant. 2006;15(10):881-3.
細胞成長抑制
▶Hibernation, reversible cell growth inhibition by epigallocatechin-3-O-gallate. J Biotechnol. 2007 Jan 20;127(4):758-64. Epub 2006 Sep 22.
真菌性感染症
▶Antifungal susceptibility of epigallocatechin 3-O-gallate (EGCg) on clinical isolates of pathogenic yeasts. Biochem Biophys Res Commun. 2006 Aug 25;347(2):401-5. Epub 2006 Jun 15.
虚血/再潅流障害
▶Effect of green tea extracted polyphenol on ischemia/reperfusion injury after cold preservation of rat lung. Transplant Proc. 2003 Feb;35(1):138-9. No abstract available.
ラット腹部大動脈瘤
▶Prevention of abdominal aortic aneurysm progression by oral administration of green tea polyphenol in a rat model. J Vasc Surg. 2016 Jul 26. pii: S0741-5214(16)30419-0. doi: 10.1016/j.jvs.2016.06.003.
