PGLA
Poly(glycolide-co-L-lactide)
Poly(glycolide-co-lactide) (PGLA) is obtained by the ring-opening co-polymerization of glycolide (cyclic dimer of glycolic acid) and lactide (cyclic dimer of lactic acid) as monomers.
Since lactide has 3 optical isomer as L-lactide, D-lactide, and DL-lactide, the copolymer of glycolide and L-lactide is abbreviated to PGLA, while the copolymer of glycolide and DL-lactide is abbreviated to PGDLLA.
| Chemical name | Poly(glycolic acid-co-L-lactic acid) Poly(glycolide-co-L-lactide) Poly[oxy(1-oxo-2-methylethylene)-co-oxy(1-oxoethylene)] Poly[oxy(2-oxoethylene)-co-oxy(1-methyl-2-oxoethylene)] |
| Chemical formula | −(C2H2O2)n−(C3H4O2)m− −O−CO−CH2−O−CO−CH(CH3)− |
| Formula weight | 130.09874 |
| CAS number | 34346−01−5, 26780−50−7 |
| Characteristics | Insoluble into general organic solvents (with the polymer having higher glycolide content) |
Typical specification of PGLA
The following shows the specification example of our PGLA polymer (PGLA(90:10))
| Testing item | Specification |
| Identification | Same as the standard NMR spectrum of PGLA. |
| Composition | CGA:CLA = 85:15 − 95:5 (mol%) |
| Inherent viscosity | ηinh = 1.3 − 1.7 (dL/g) [0.1 g/dL HFIP, 25 ℃] |
| Melting point（Tm） | 205 ≤ Tm ≤ 215 (℃) |
| Particle size | Not passing 500 µm mesh screen. |
| Appearance | No contamination by foreign objects Normal coloring (beige or tan/khaki or ivory) (Sensory test with eye) |
※If you have the specific requirement for PGLA polymer, please feel free to ask us.
Potential application of PGLA
PGLA polymer with higher content of glycolide and having similar properties with PGA is mainly applied for absorbable suture. PGLA filament is used as multifilament because the filament obtained from PGLA with higher content of glycolide is also rigid and less flexible.
Applicable examples of the medical device obtained from PGLA polymers are shown with color in follows:
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